Phosphoryl Transfer by Protein Kinase A Is Captured in a Crystal Lattice
J. Am. Chem. Soc., 2013, 135 (12), pp 4788–4798
DOI: 10.1021/ja312237q
Nice paper where the authors show phosphoryl transfer on an atomic scale. Pretty neat that the supposedly non-hydrolyzable ATP (AMP-PNP) was actually a capable co-substrate. Also interesting how slow catalysis occurs in the crystal lattice, judging from the fact that they essentially performed a crystallographic timecourse experiment over several months.
