Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli
Neat paper on how the protein Shc prevents Erk activation. Apparently Shc binds directly to Erk, but then dissociates upon activation of EGFR. No x-ray structure of the complex, but a SAXS model showed the phosphotyrosine-binding domain of Shc clamping onto the N-lobe of Erk. From a mechanistic standpoint, I wonder how Shc binding prevents Erk phosphorylation by MEK.
