Bivalent JNK inhibitor

A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

ACS Chem. Biol., Article ASAP

http://pubs.acs.org/doi/abs/10.1021/cb3006165

I'm a big fan of the LoGrasso group's work on JNKs. Here they used a bivalent approach to target both the adenosine pocket and the substrate-binding pocket.